| García, M.A., Paulos, C., Ibarra Viñales, M., Michelet, R., Cabrera-Pérez, M.A., Aceituno, A., Bone, M., Ibacache, M., Cortínez, L.I., Guzmán, M. |
Modeling and Simulations in Latin-American Generic Markets: Perspectives from Chilean Local Industry, Regulatory Agency, and Academia |
In the last 20 years, modeling and simulations (M&S) have gained increased attention in pharmaceutical sciences. International industry and world-reference agencies have used M&S to make cost-efficien... |
2024 |
21 |
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| Arteta-Acosta, C., Villena, R., Hormazabal, J.C., Fernández, J., Santolaya, M.E. |
Whole-genome sequencing of Neisseria meningitidis collected in Chile from pediatric patients during 2016–2019 and coverage vaccine prediction |
Background: Over the past few years, whole-genome sequencing (WGS) has become a valuable tool for global meningococcal surveillance. The objective of this study was to genetically characterize Neisser... |
2024 |
42 |
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| García, M.A., González, P.M., Aceituno, A., Al-Gousous, J. |
Corrigendum to Novel analytical solutions for convolution in compartmental pharmacokinetic models and application to non-bioequivalent formulations [European Journal of Pharmaceutical Sciences 202 (2024) 1–10/106892] (S0928098724002045), (10.1016/j.ejps.2024.106892) |
The authors regret having to inform that an error was found in the article. The statement "To the best of our knowledge, comprehensive equations for the aforementioned cases have not been reported so ... |
2024 |
203 |
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| Blukacz, A., Oyarte, M., Cabieses, B. |
Adequate housing as a social determinant of the health of international migrants and locals in Chile between 2013 and 2022 |
Background: Adequate housing is a fundamental right and a social determinant of health. It also represents a historically contentious topic in Latin America. Migratory flows to Chile have become incre... |
2024 |
24 |
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| Oróstica, K.Y., Mohr, S.B., Dehning, J., Bauer, S., Medina-Ortiz, D., Iftekhar, E.N., Mujica, K., Covarrubias, P.C., Ulloa, S., Castillo, A.E., Daza-Sánchez, A., Verdugo, R.A., Fernández, J., Olivera-Nappa, Á., Priesemann, V., Contreras, S. |
Early mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile |
Genomic surveillance (GS) programmes were crucial in identifying and quantifying the mutating patterns of SARS-CoV-2 during the COVID-19 pandemic. In this work, we develop a Bayesian framework to quan... |
2024 |
14 |
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| Gálvez-Silva, M., Arros, P., Berríos-Pastén, C., Villamil, A., Rodas, P.I., Araya, I., Iglesias, R., Araya, P., Hormazábal, J.C., Bohle, C., Chen, Y., Gan, Y.-H., Chávez, F.P., Lagos, R., Marcoleta, A.E. |
Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile |
Background: The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) ... |
2024 |
57 |
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| Gräf, T., Martinez, A.A., Bello, G., Dellicour, S., Lemey, P., Colizza, V., Mazzoli, M., Poletto, C., Cardoso, V.L.O., da Silva, A.F., Baumeister, E., Campos, J., Pontoriero, A., Martin, I., Ferguson, K., Johnson, D., Beckles, S., Forde, K., Sosa, A., Melendez, R., Loayza, R., Avila, C., Fernández, E.E.F., Otazo, C.J.G., Siqueira, M.M., Motta, F.C., de Oliveira Santos, K.C., Abbud, A., dos Santos, M.C., de Almeida Ferreira, J., Fasce, R., Fernandes, J., Rangel, S.G., Mercado, M.M., Pelaez, D., Soto-Garita, C., Cordero-Laurent, E., Duarte-Martínez, F., Brenes, H., Sanchez, I.M., Imbert, Y., Caicedo, A.B., de Mora Coloma, D.J., López, D.X.S., Alvarado, D.G.J., Morán, D.L.M., Pacheco, C., Mendoza, L., Whyte-Chin, J., Abdul-Kadir, M., Boncy, J., Journel, I., Paz, M.C., Alvarado, S.C., Avilez, S., Brown, M., Arambula, C.E.W., González, E.R., Martinez, A.A., Gonzalez, C.M., Moreno Arevalo, B., Franco, D., Lopez-Verges, S., Pascale, J.M., Vazquez, C., Gonzalez, S., Serrano, N.R., Rojas, C.P.P., Pinas, P., Asebeh, N., Carrington, C.V.F., Sahadeo, N.S.D., Chiparelli, H., Goñi, N., Rodriguez, L., D’Angelo, P., Motta, F.C., Resende, P.C., Siqueira, M.M., Franco, L., Gresh, L., Gabastou, J.-M., Rodriguez, A., Vicari, A., Aldighieri, S., Mendez-Rico, J., Leite, J.A., COVIGEN |
Dispersion patterns of SARS-CoV-2 variants Gamma, Lambda and Mu in Latin America and the Caribbean |
Latin America and Caribbean (LAC) regions were an important epicenter of the COVID-19 pandemic and SARS-CoV-2 evolution. Through the COVID-19 Genomic Surveillance Regional Network (COVIGEN), LAC count... |
2024 |
15 |
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| Gutierrez, B., Tsui, J.L.-H., Pullano, G., Mazzoli, M., Gangavarapu, K., Inward, R.P.D., Bajaj, S., Pena, R.E., Busch-Moreno, S., Suchard, M.A., Pybus, O.G., Dunner, A., Puentes, R., Ayala, S., Fernandez, J., Araos, R., Ferres, L., Colizza, V., Kraemer, M.U.G. |
Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile |
Human mobility is strongly associated with the spread of SARS-CoV-2 via air travel on an international scale and with population mixing and the number of people moving between locations on a local sca... |
2024 |
3 |
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| García, M.A., González, P.M., Aceituno, A., Al-Gousous, J. |
Novel analytical solutions for convolution in compartmental pharmacokinetic models and application to non-bioequivalent formulations |
Deconvolution and convolution are powerful tools that allow decomposition and reconstruction, respectively, of plasma versus time profiles from input and impulse functions. While deconvolution have co... |
2024 |
202 |
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| Prunas, O., Shioda, K., Toscano, C.M., Bastias, M., Valenzuela-Bravo, M.T., Tito, J.D., Warren, J.L., Weinberger, D.M., De Oliveira, L.H. |
Estimated Population-Level Impact of Pneumococcal Conjugate Vaccines Against All-Cause Pneumonia Mortality Among Unvaccinated in 5 Latin American Countries |
Background: Pneumococcal conjugate vaccines (PCVs) provide strong direct protection in children, while limited data are available on their indirect effect on mortality among older age groups. This mul... |
2024 |
230 |
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| Ramírez, M.A., Loaiza, R.A., Martínez-Balboa, Y., Bruneau, N., Ramírez, E., González, P.A., Bueno, S.M., Kalergis, A.M. |
Co-administration of recombinant BCG and SARS-CoV-2 proteins leads to robust antiviral immunity |
SARS-CoV-2 is the causative virus of COVID-19, which has been responsible for millions of deaths worldwide since its discovery. After its emergence, several variants have been identified that challeng... |
2024 |
42 |
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| Campaña, C., Oyarte, M., Cabieses, B., Obach, A. |
Breast cancer diagnosis and staging in Chile: A non-randomized survey-based study to assess frequency and delays |
INTRODUCTION Breast cancer progression involves physiological mechanisms such as metastasis. Delays in diagnosis and treatment increase the risk of mortality and are associated with barriers to health... |
2024 |
24 |
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| González, C.R., Reyes, C., Castillo, A., Valderrama, L., Llanos, L., Fernández, J., Eastwood, G., Cancino-Faure, B. |
Molecular evidence of pathogens and endosymbionts in the black horse fly Osca lata (Diptera: Tabanidae) in Southern Chile |
Little is known about the role of horse flies in potential pathogen transmission in Chile. This study provides evidence of the molecular detection of microorganisms in southern Chile. In the present s... |
2024 |
18 |
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| Opazo-Capurro, A., Xanthopoulou, K., Arazo del Pino, R., González-Muñoz, P., Matus-Köhler, M., Amsteins-Romero, L., Jerez-Olate, C., Hormazábal, J.C., Vera, R., Aguilera, F., Fuller, S., Higgins, P.G., González-Rocha, G. |
Co-Occurrence of Two Plasmids Encoding Transferable blaNDM-1 and tet(Y) Genes in Carbapenem-Resistant Acinetobacter bereziniae |
Acinetobacter bereziniae has emerged as a significant human pathogen, acquiring multiple antibiotic resistance genes, including carbapenemases. This study focuses on characterizing the plasmids harbor... |
2024 |
15 |
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| Lagos, R.M., Sikorski, M.J., Hormazábal, J.C., Fernandez, A., Duarte, S., Pasetti, M.F., Rasko, D.A., Higginson, E., Nkeze, J., Kasumba, I.N., Dougan, G., Maes, M., Lees, A., Tennant, S.M., Levine, M.M. |
Detecting Residual Chronic Salmonella Typhi Carriers on the Road to Typhoid Elimination in Santiago, Chile, 2017-2019 |
Background: In Santiago, Chile, where typhoid had been hyperendemic (1977-1991), we investigated whether residual chronic carriers could be detected among household contacts of non-travel-related typh... |
2024 |
230 |
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| Díaz-Dinamarca, D.A., Cárdenas-Cáceres, S., Muena, N.A., Díaz, P., Barra, G., Puentes, R., Escobar, D.F., Díaz-Samirin, M., Santis-Alay, N.T., Canales, C., Díaz, J., García-Escorza, H.E., Grifoni, A., Sette, A., Tischler, N.D., Vasquez, A.E. |
Booster Vaccination with BNT162b2 Improves Cellular and Humoral Immune Response in the Pediatric Population Immunized with CoronaVac |
The SARS-CoV-2 Omicron variant and its sublineages continue to cause COVID-19-associated pediatric hospitalizations, severe disease, and death globally. BNT162b2 and CoronaVac are the main vaccines us... |
2024 |
12 |
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| Bernal, Y.A., Durán, E., Solar, I., Sagredo, E.A., Armisén, R. |
ADAR-Mediated A>I(G) RNA Editing in the Genotoxic Drug Response of Breast Cancer |
Epitranscriptomics is a field that delves into post-transcriptional changes. Among these modifications, the conversion of adenosine to inosine, traduced as guanosine (A>I(G)), is one of the known RNA-... |
2024 |
25 |
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| Kochhar, S., Assis, D.N., Mack, C., Izurieta, H.S., Muratori, L., Munoz, A., Nordenberg, D., Gidudu, J.F., Blau, E.F., Vierling, J.M. |
Autoimmune hepatitis: Brighton Collaboration case definition and guidelines for data collection, analysis, and presentation of immunisation safety data |
This report introduces a Brighton Collaboration (BC) case definition for autoimmune hepatitis (AIH), which has been classified as a priority adverse event of special interest (AESI), as there were pos... |
2024 |
42 |
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| Iribarren, C., Plaza, N., Ramírez-Araya, S., Pérez-Reytor, D., Urrutia, Í.M., Suffredini, E., Vicenza, T., Ulloa, S., Fernández, J., Navarrete, P., Jaña, V., Pavez, L., del Pozo, T., Corsini, G., Lopez-Joven, C., García, K. |
Presence of Zonula Occludens Toxin-Coding Genes among Vibrio parahaemolyticus Isolates of Clinical and Environmental Origin |
In recent studies, emphasis has been placed on the zonula occludens toxin (Zot) from the non-toxigenic Vibrio parahaemolyticus strain PMC53.7 as an agent inducing alterations in the actin cytoskeleton... |
2024 |
12 |
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| Navarrete, J., Oyarce, A., Oliva, B., Lozano, C., Amarales, C., Cordero, E.M., Riveros, R., Carvajal, Y., Canals, M. |
Granulomatous amoebic encephalitis due to Balamuthia mandrillaris in Chile confirmed with DNA sequencing |
Diseases caused by free-living amoebae are opportunistic infections that can have a fatal course. They can cause very serious disseminated conditions with involvement of the central nervous system suc... |
2024 |
41 |
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