Instituto de Salud Pública

Autor(es) Titulo Resumen Año Volumen Ver Más
Rivera-Pérez, Daniela- Méndez, Constanza- Diethelm-Varela, Benjamín- Melo-González, Felipe- Vázquez, Yaneisi- Meng, Xing- Xin, Qianqian- Fasce, Rodrigo A.- Fernández, Jorge- Mora, Judith- Ramirez, Eugenio- Acevedo, Mónica L.- Valiente-Echeverría, Fernando- Soto-Rifo, Ricardo- Grifoni, Alba- Weiskopf, Daniela- Sette, Alessandro- Astudillo, Patricio- Le Corre, Nicole- Abarca, Katia- Perret, Cecilia- González, Pablo A.- Soto, Jorge A.- Bueno, Susan M.- Kalergis, Alexis M. Immune responses during COVID-19 breakthrough cases in vaccinated children and adolescents BACKGROUND: Vaccine effectiveness against SARS-CoV-2 infection has been somewhat limited due to the widespread dissemination of the Omicron variant, its subvariants, and the immune response dynamics o... 2024 15 Ver Más
Iribarren, Cristian- Plaza, Nicolás- Ramírez-Araya, Sebastián- Pérez-Reytor, Diliana- Urrutia, Ítalo M.- Suffredini, Elisabetta- Vicenza, Teresa- Ulloa, Soledad- Fernández, Jorge- Navarrete, Paola- Jaña, Victor- Pavez, Leonardo- Del Pozo, Talía- Corsini, Gino- Lopez-Joven, Carmen- García, Katherine Presence of Zonula Occludens Toxin-Coding Genes among Vibrio parahaemolyticus Isolates of Clinical and Environmental Origin In recent studies, emphasis has been placed on the zonula occludens toxin (Zot) from the non-toxigenic Vibrio parahaemolyticus strain PMC53.7 as an agent inducing alterations in the actin cytoskeleton... 2024 12 Ver Más
Salerno-Goncalves, Rosângela- Chen, Haiyan- Bafford, Andrea C.- Izquierdo, Mariana- Hormazábal, Juan Carlos- Lagos, Rosanna- Tettelin, Hervé- D'Mello, Adonis- Booth, Jayaum S.- Fasano, Alessio- Levine, Myron M.- Sztein, Marcelo B. Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis Salmonella enterica serovar Typhi (S. Typhi), a human-restricted pathogen, invades the host through the gut to cause typhoid fever. Recent calculations of the typhoid fever burden estimated that more ... 2024 15 Ver Más
Prunas, Ottavia- Shioda, Kayoko- Toscano, Cristiana M.- Bastias, Magdalena- Valenzuela-Bravo, Maria Teresa- Diaz Tito, Janepsy- Warren, Joshua L.- Weinberger, Daniel M.- de Oliveira, Lucia H. Estimated population-level impact of pneumococcal conjugate vaccines against all-cause pneumonia mortality among unvaccinated age groups in five Latin American countries BACKGROUND: Pneumococcal conjugate vaccines (PCVs) provide strong direct protection in children, while limited data are available on their indirect effect on mortality among older age groups. This mul... 2024 Ver Más
Kochhar, Sonali- Assis, David N.- Mack, Cara- Izurieta, Hector S.- Muratori, Luigi- Munoz, Alma- Nordenberg, Dale- Gidudu, Jane F.- Blau, Erin F.- Vierling, John M. Autoimmune hepatitis: Brighton Collaboration case definition and guidelines for data collection, analysis, and presentation of immunisation safety data This report introduces a Brighton Collaboration (BC) case definition for autoimmune hepatitis (AIH), which has been classified as a priority adverse event of special interest (AESI), as there were pos... 2024 42 Ver Más
Gálvez-Silva, M.- Arros, P.- Berríos-Pastén, C.- Villamil, A.- Rodas, P.I.- Araya, I.- Iglesias, R.- Araya, P.- Hormazábal, J.C.- Bohle, C.- Chen, Y.- Gan, Y.-H.- Chávez, F.P.- Lagos, R.- Marcoleta, A.E. Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile Background: The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) ... 2024 57 Ver Más
Retamales, J.- Daneri-Navarro, A.- Artagaveytia, N.- Alves da Quinta, D.- Abdelhay, E.- Podhajcer, O.L.- Velázquez, C.- Giunta, D.- Crocamo, S.- Garibay-Escobar, A.- Del Toro-Arreola, A.- Rodriguez, R.- Aghazarian, M.- Alcoba, E.- Alonso, I.- Binato, R.- Bravo, A.I.- Canton-Romero, J.- Carraro, D.M.- Castro, M.- Castro-Cervantes, J.- Cataldi, S.- Camejo, N.- Cortes-Sanabria, L.- Flores-Marquez, M.- Laviña, G.- Musetti, E.- Caserta, B.- Cerda, M.- Colombo, A.- Delgadillo-Cristerna, R.- Dreyer Breitenbach, M.- Fernandez, E.- Fernandez, J.- Franco-Topete, R.- Gabay, C.- Gaete, F.- Gamboa, J.- García-Gaeta, R.- Gomez Del Toro, M.- Gonzalez-Ramirez, L.P.- Guerrero, M.- Herrera-Miramontes, M.- Lopez-Vasquez, A.- Maldonado, S.- Morán-Mendoza, A.- Morgan-Villela, G.- Nagai, M.A.- Navarro-Ruiz, N.- Oceguera-Villanueva, A.- Ortiz, M.A.- Quintero, J.- Quintero-Ramos, A.- Ramirez-Rosales, G.- Ramos-Ramirez, M.- Chiquitelli Marques, M.M.- Rivera Claisse, E.- Rodriguez-Gonzalez, D.- Romero-Gomez, A.- Rosales, C.- Salas-Gonzalez, E.- Sanchotena, V.- Segovia, L.- Silva-García, A.A.- Valenzuela-Antelo, O.- Venegas-Godinez, L.- Zagame, L.- Gomez, J.- Llera, A.S.- Müller, B.- Latin, American Cancer Research Network (LACRN) Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial PURPOSE: Breast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable mole... 2024 10 Ver Más
Navarrete, J.- Oyarce, A.- Oliva, B.- Lozano, C.- Amarales, C.- Cordero, E.M.- Riveros, R.- Carvajal, Y.- Canals, M. Granulomatous amoebic encephalitis due to Balamuthia mandrillaris in Chile confirmed with DNA sequencing Diseases caused by free-living amoebae are opportunistic infections that can have a fatal course. They can cause very serious disseminated conditions with involvement of the central nervous system suc... 2024 41 Ver Más
Lagos, Rosanna M.- Sikorski, Michael J.- Hormazábal, Juan Carlos- Fernandez, Alda- Duarte, Sergio- Pasetti, Marcela F.- Rasko, David A.- Higginson, Ellen- Nkeze, Joseph- Kasumba, Irene N.- Dougan, Gordon- Maes, Mailis- Lees, Andrew- Tennant, Sharon M.- Levine, Myron M. Detecting residual chronic Salmonella Typhi carriers on the road to typhoid elimination in Santiago, Chile, 2017-2019 OBJECTIVES: In Santiago, Chile, where typhoid had been hyperendemic (1977-1991), we investigated whether residual chronic carriers could be detected among household contacts of non-travel-related typh... 2023 Ver Más
Aburto, Andrés- Zapata, Diego- Retamales, Eduardo- Fernández, Jorge- Barra, Gisselle- Peña, Francisca- Cárcamo, Sofía- Saavedra, Nicolás- Sandoval, Cristian- Orellana, Juan- Caamaño, José Genotype analysis to clarify RhD variants in discrepant samples of Chilean population INTRODUCTION: The D antigen variants are classified as weak, partial, and extremely weak (DEL) and can be differentiated using molecular tests. In Chile, the laboratories of local blood centers do not... 2023 14 Ver Más
Lobos-González, Lorena- Oróstica, Lorena- Díaz-Valdivia, Natalia- Rojas-Celis, Victoria- Campos, America- Duran-Jara, Eduardo- Farfán, Nicole- Leyton, Lisette- Quest, Andrew F. G. Prostaglandin E2 Exposure Disrupts E-Cadherin/Caveolin-1-Mediated Tumor Suppression to Favor Caveolin-1-Enhanced Migration, Invasion, and Metastasis in Melanoma Models Caveolin-1 (CAV1) is a membrane-bound protein that suppresses tumor development yet also promotes metastasis. E-cadherin is important in CAV1-dependent tumor suppression and prevents CAV1-enhanced lun... 2023 24 Ver Más
Rojas-Sereno, Zulma Esperanza- Streicker, Daniel G.- Suarez-Yana, Tania- Lineros, Michelle- Yung, Verónica- Godreuil, Sylvain- Benavides, Julio A. Detection of antimicrobial-resistant Enterobacterales in insectivorous bats from Chile Enterobacterales of clinical importance for humans and domestic animals are now commonly detected among wildlife worldwide. However, few studies have investigated their prevalence among bats, particul... 2023 10 Ver Más
Quinteros, María Elisa- Blazquez, Carola- Ayala, Salvador- Kilby, Dylan- Cárdenas-R, Juan Pablo- Ossa, Ximena- Rosas-Diaz, Felipe- Stone, Elizabeth A.- Blanco, Estela- Delgado-Saborit, Juana-María- Harrison, Roy M.- Ruiz-Rudolph, Pablo Development of Spatio-Temporal Land Use Regression Models for Fine Particulate Matter and Wood-Burning Tracers in Temuco, Chile Biomass burning is common in much of the world, and in some areas, residential wood-burning has increased. However, air pollution resulting from biomass burning is an important public health problem. ... 2023 57 Ver Más
Romero F, Patricia- Ramírez V, Eugenio- Muñoz O, Mónica- Muñoz M, Paula- González L, Carolina- Orellana C, Carolina- Pastene S, Carolina- Balanda A, Montserrat- Vergara V, Nicolás- Reyes P, Alvaro [Anogenital lesions produced by Human Papillomavirus. Prevalence study in children and adolescent not vaccinated] In Chilean children and adolescents, human papillomavirus (HPV) infection prevalence is unknown. In 2014, the HPV vaccine was incorporated into the National Immunization Program for girls, and since 2... 2023 94 Ver Más
Díaz-Dinamarca, Diego A.- Salazar, Michelle L.- Escobar, Daniel F.- Castillo, Byron N.- Valdebenito, Bastián- Díaz, Pablo- Manubens, Augusto- Salazar, Fabián- Troncoso, Mayarling F.- Lavandero, Sergio- Díaz, Janepsy- Becker, María Inés- Vásquez, Abel E. Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways The development of vaccine adjuvants is of interest for the management of chronic diseases, cancer, and future pandemics. Therefore, the role of Toll-like receptors (TLRs) in the effects of vaccine ad... 2023 14 Ver Más
Carey, Megan E.- Dyson, Zoe A.- Ingle, Danielle J.- Amir, Afreenish- Aworh, Mabel K.- Chattaway, Marie Anne- Chew, Ka Lip- Crump, John A.- Feasey, Nicholas A.- Howden, Benjamin P.- Keddy, Karen H.- Maes, Mailis- Parry, Christopher M.- Van Puyvelde, Sandra- Webb, Hattie E.- Afolayan, Ayorinde Oluwatobiloba- Alexander, Anna P.- Anandan, Shalini- Andrews, Jason R.- Ashton, Philip M.- Basnyat, Buddha- Bavdekar, Ashish- Bogoch, Isaac I.- Clemens, John D.- da Silva, Kesia Esther- De, Anuradha- de Ligt, Joep- Diaz Guevara, Paula Lucia- Dolecek, Christiane- Dutta, Shanta- Ehlers, Marthie M.- Francois Watkins, Louise- Garrett, Denise O.- Godbole, Gauri- Gordon, Melita A.- Greenhill, Andrew R.- Griffin, Chelsey- Gupta, Madhu- Hendriksen, Rene S.- Heyderman, Robert S.- Hooda, Yogesh- Hormazabal, Juan Carlos- Ikhimiukor, Odion O.- Iqbal, Junaid- Jacob, Jobin John- Jenkins, Claire- Jinka, Dasaratha Ramaiah- John, Jacob- Kang, Gagandeep- Kanteh, Abdoulie- Kapil, Arti- Karkey, Abhilasha- Kariuki, Samuel- Kingsley, Robert A.- Koshy, Roshine Mary- Lauer, A. C.- Levine, Myron M.- Lingegowda, Ravikumar Kadahalli- Luby, Stephen P.- Mackenzie, Grant Austin- Mashe, Tapfumanei- Msefula, Chisomo- Mutreja, Ankur- Nagaraj, Geetha- Nagaraj, Savitha- Nair, Satheesh- Naseri, Take K.- Nimarota-Brown, Susana- Njamkepo, Elisabeth- Okeke, Iruka N.- Perumal, Sulochana Putli Bai- Pollard, Andrew J.- Pragasam, Agila Kumari- Qadri, Firdausi- Qamar, Farah N.- Rahman, Sadia Isfat Ara- Rambocus, Savitra Devi- Rasko, David A.- Ray, Pallab- Robins-Browne, Roy- Rongsen-Chandola, Temsunaro- Rutanga, Jean Pierre- Saha, Samir K.- Saha, Senjuti- Saigal, Karnika- Sajib, Mohammad Saiful Islam- Seidman, Jessica C.- Shakya, Jivan- Shamanna, Varun- Shastri, Jayanthi- Shrestha, Rajeev- Sia, Sonia- Sikorski, Michael J.- Singh, Ashita- Smith, Anthony M.- Tagg, Kaitlin A.- Tamrakar, Dipesh- Tanmoy, Arif Mohammed- Thomas, Maria- Thomas, Mathew S.- Thomsen, Robert- Thomson, Nicholas R.- Tupua, Siaosi- Vaidya, Krista- Valcanis, Mary- Veeraraghavan, Balaji- Weill, François-Xavier- Wright, Jackie- Dougan, Gordon- Argimón, Silvia- Keane, Jacqueline A.- Aanensen, David M.- Baker, Stephen- Holt, Kathryn E.- Global Typhoid Genomics Consortium Group Authorship Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes BACKGROUND: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to i... 2023 12 Ver Más
Díaz-Dinamarca, Diego A.- Díaz, Pablo- Barra, Gisselle- Puentes, Rodrigo- Arata, Loredana- Grossolli, Jonnathan- Riveros-Rodriguez, Boris- Ardiles, Luis- Santelises, Julio- Vasquez-Saez, Valeria- Escobar, Daniel F.- Soto, Daniel- Canales, Cecilia- Díaz, Janepsy- Lamperti, Liliana- Castillo, Daniela- Urra, Mychel- Zuñiga, Felipe- Ormazabal, Valeska- Nova-Lamperti, Estefanía- Benítez, Rosana- Rivera, Alejandra- Cortes, Claudia P.- Valenzuela, María Teresa- García-Escorza, Heriberto E.- Vasquez, Abel E. Humoral immunity against SARS-CoV-2 evoked by heterologous vaccination groups using the CoronaVac (Sinovac) and BNT162b2 (Pfizer/BioNTech) vaccines in Chile INTRODUCTION: Severe acute respiratory syndrome virus 2 (SARS-CoV-2) has caused over million deaths worldwide, with more than 61,000 deaths in Chile. The Chilean government has implemented a vaccinati... 2023 11 Ver Más
Sepúlveda, Francisca- Mayorga-Lobos, Cristina- Guzmán, Kevin- Durán-Jara, Eduardo- Lobos-González, Lorena EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment Cancer research has prioritized the study of the tumor microenvironment (TME) as a crucial area of investigation. Understanding the communication between tumor cells and the various cell types within ... 2023 24 Ver Más
Machado, Fernanda Lacerda da Silva- Cañás, Martín- Doubova, Svetlana V.- Urtasun, Martín A.- Marín, Gustavo H.- Osorio-de-Castro, Claudia Garcia Serpa- Albuquerque, Flavia Caixeta- Ribeiro, Tatiane Bonfim- Pont, Lisa- Crisóstomo Landeros, José- Roldán Saelzer, Juan- Sepúlveda Viveros, Dino- Acosta, Angela- Machado Beltrán, Manuel A.- Gordillo Alas, Lily Iracema- Orellana Tablas, Lourdes Abigail- Benko, Ria- Convertino, Irma- Bonaso, Marco- Tuccori, Marco- Kirchmayer, Ursula- Contreras Sánchez, Saúl E.- Rodríguez-Tanta, L. Yesenia- Gutierrez Aures, Ysabel- Lin, Boya- Alipour-Haris, Golnoosh- Eworuke, Efe- Lopes, Luciane Cruz Biosimilars approvals by thirteen regulatory authorities: A cross-national comparison Biosimilars are biological medicines highly similar to a previously licensed reference product and their licensing is expected to improve access to biological therapies. This study aims to present an ... 2023 144 Ver Más
Estallo, Elizabet L., Sippy, Rachel, Robert, Michael A., Ayala, Salvador, Barboza Pizard, Carlos J., Pérez-Estigarribia, Pastor E., Stewart-Ibarra, Anna M. Increasing arbovirus risk in Chile and neighboring countries in the Southern Cone of South America ... 2023 23 Ver Más